The San Francisco 49ers can clinch a playoff berth in Week 16 with a win over the Indianapolis Colts or a Detroit Lions loss to the Pittsburgh Steelers.

Despite the missed opportunity to gain ground, the 49ers improved to 10-4 and remain firmly in the playoff hunt with three games left on the schedule. San Francisco will travel to face the Indianapolis Colts in Week 16 before closing the regular season with home games against the Chicago Bears and the Seahawks.

If these two things happen, the 49ers would finish 13-4 and win the NFC West over a 13-4 Rams team based on the division record tiebreaker. If the Seahawks also finish 13-4 in this scenario, the 49ers would have swept them, so they'd win any tiebreaker with Seattle. At 7-to-1 odds to win the NFC West, the 49ers feel like a steal.

Everything you need to know about the Rams vs. San Francisco 49ers in Week 10 of the NFL season, including how to watch and a prediction on who will win.

How do all 32 teams in the NFL stack up against each other coming out of Week 15 of the 2025 NFL regular season? Here's an updated look from best to worst.

The 49ers can clinch a playoff berth in Week 16 with a win over the Colts — or with help before kickoff. Here's how San Francisco gets in.

The San Francisco 49ers beat the Tennessee Titans on Sunday. How did their performance affect their standing heading into Week 16?

With the win, San Francisco’s win streak improved to four games, and it remained a half-game back of both the Seattle Seahawks and Los Angeles Rams for the division lead. With three games left, the 49ers are in a great position to make the playoffs,