Graphical Abstract: Antidepressant drugs act by directly binding to TrkB neurotrophin receptors. Source: Casarotto et al., 2021/open-access paper in Cell (CC BY 4.0) Key Points: A new study challenges ...

A recent study sheds light on the mechanisms of neural plasticity induced by the antidepressant fluoxetine. A recent study, published in Neuropsychopharmacology, conducted by researchers from the ...

In response to the question of how psychedelics can prove effective in treating mental health conditions like depression, an international neuroscience team seems to have found a new answer.

In a recent study published in the journal Nature, researchers investigate whether persistent blocking of N-methyl-D-aspartate receptor (NMDAR) and burst-type firing by lateral habenula (LHb) neurons ...

A study published in Biological Psychiatry investigated the role of the 5-HT4 receptor (5-HT4R) in patients with major depressive disorder (MDD) and how changes in this receptor may relate to the ...

Activation of the body’s opioid system may be required for ketamine’s antidepressant effects, new research hinted. In a small study of adults with major depressive disorder, taking the opioid blocker ...

Depression continues to grapple a large proportion of the population. Given the side effects associated with the long-term use of conventional antidepressants, there is a need for novel rapid acting ...