This article describes a method for assessing the similarity of dissolution profiles using Hotelling's T2 statistic. The method applies a covariance structure that accounts for the heterogeneity of ...

In the manufacture of solid dosage forms, the rate at which the active pharmaceutical ingredient (API) is dissolved into solvents simulating the digestive tract fluids is determined with dissolution ...

Numerous therapeutic advantages are offered by sustained-release drugs, which release active pharmaceutical ingredients (APIs) in a gradual manner. However, the QC of such drugs through conventional ...