(a) Within this simple eukaryotic transcriptional unit, a simple core promoter (TATA), an upstream activator sequence (UAS), and a silencer element are spaced within 100 to 200 base pairs of the TATA ...

This study identifies around 11,000 housekeeping cis-regulatory elements (HK-CREs), revealing their important role in cellular stability and potential tumor suppression capability across diverse ...

Yeast is a single cell eukaryotic organism, that incites in this Irish scientist an intense memory of the smell of brewing Guinness, wafting down the River Liffey on a drizzly Dublin day as I sit at ...

In high-precision bioengineering and synthetic biology, the fine-tuning of gene expression at transcriptional and posttranscriptional levels is essential. This involves a detailed understanding and ...

Different mechanisms have been proposed to explain the specificity of enhancer-promoter interactions, including promoter competition and insulator DNA elements. In the 9 July Proceedings of the ...