DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave.

MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...

R-loops are structures that form when a strand of RNA (red) forms a stable structure with double-stranded DNA, causing one strand of the DNA to form a loop. R-loops are associated with gene ...

Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic ...