“ANCA-associated vasculitis is associated with increased early mortality and a high risk of end-stage renal disease,” Peter A. Merkel, MD, MPH, chief of rheumatology and a professor of medicine and ...

Exposure of the fetus to excess glucocorticoids leads to long-term programming of the function of the hypothalamic–pituitary–adrenal (HPA) axis and the behaviour of the organism A number of ...

Glucocorticoids, the hormones released into the blood by the adrenal glands, are essential for survival, but prolonged exposure to high glucocorticoid levels — such as during chronic stress — has ...

Glucocorticoids (GCs) are widely prescribed anti-inflammatory agents, but their chronic use leads to undesirable side effects such as excessive expansion of adipose tissue. We have recently shown that ...

Deciphering how the GR forms oligomers — through the binding of several subunits — opens a crucial avenue for developing more selective drugs. These new drugs could modulate this association and thus ...

Please provide your email address to receive an email when new articles are posted on . Children and adolescents with congenital adrenal hyperplasia, or CAH, diagnosed early via a neonatal screening ...

Patients with Duchenne muscular dystrophy (DMD) are prescribed corticosteroid anti-inflammatory drugs as standard of care, but long-term use comes with significant adverse effects. For individuals ...