Accurate chromosome segregation and cell division are central to maintaining genomic integrity and ensuring proper development and tissue homeostasis. These processes rely on a complex network of ...
Unraveling metabolic regulation in aneuploid tumor cells: Key insights for targeted cancer therapies
A research team led by Professor YANG Zhenye from the Division of Life Sciences and Medicine, the University of Science and Technology of China (USTC) of Chinese Academy of Sciences (CAS), in ...
Mitotic segregation of chromosomes depends on correct assembly of the bipolar spindle and mitosis is delayed by the spindle assembly checkpoint (SAC). In the July 19 Nature, Gachet et al., at the ...
A, Under normal conditions, the Bub1 acetylation/deacetylation cycle regulates the kinase activity of Bub1 and thereby promotes the recruitment of CPC and Sgo1 to ...
Proper chromosome segregation into two future daughter cells requires the mitotic spindle to elongate in anaphase. However, although some candidate proteins are implicated in this process, the ...
For a living cell to divide successfully, each daughter cell must inherit the correct genetic material. In eukaryotes, segregation of duplicated chromosomes is performed by the mitotic spindle, a ...
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