In humans, hundreds of proteins interact in a complex network dubbed the interactome. Those interactions are further complicated when disease-causing mutations are introduced into genes that code for ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein has a C-terminus with a PDZ binding motif (PBM) that targets PDZ (PSD-95/Dlg/ZO ...

An international research team reveals new molecular mechanisms associated with pathogenic mutations in the protein ...

A series of experiments reveal that a germline mutation of the enzyme topoisomerase II B affects the movement of proteins in the nuclei of cells with this mutation The processes of DNA replication and ...

In a recent study published in PLOS Pathogens, researchers investigated a highly variable region at residues 203 to 205 in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid ...

This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...

A University of Massachusetts Amherst scientist has discovered that a mutation in the misfolding protein that causes Parkinson’s disease offers protection against another fatal neurodegenerative ...

A new single-cell profiling technique has mapped pre-malignant gene mutations and their effects in solid tissues for the ...

Nearly 1 in 7 adults in the United States lives with chronic kidney disease, a condition that often advances quietly until ...

A new mega-database of half a million mutations may flag new ways of treating genetic disease, scientists say. When you purchase through links on our site, we may earn an affiliate commission. Here’s ...