DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave.

- Research published in Molecular Cell used INDUCE-seq to identify DNA topology as an important regulator of CRISPR targeting specificity - Peer-reviewed data demonstrates the sensitivity of ...

Enzymes that cut DNA at specific sites are called endonucleases; these enzymes play many roles in genomic replication, fidelity, and defense. The initial discovery of restriction endonucleases in the ...

Researchers have identified the specific structural loops in G-quadruplex DNA that allow it to act as a chaperone, preventing ...

The first crystal structure of an alternative DNA shape from the insulin gene has been revealed by a UCL-led research team. DNA is widely accepted to be formed of two strands that wind around one ...

In the middle of the 20th century, accumulating data suggested that DNA carries life’s genetic information. Biochemists around the world raced to determine its structure. The competition led to some ...

New work from UC Davis and the University of Utah shows how the 3D structure of DNA inside a germ cell commits it to develop into a sperm cell. The discovery could improve understanding of fertility ...

For James Watson, DNA was everything — not just his life's work, but the secret of life itself. Over his long and storied career, Watson arguably did more than any other scientist to transform a ...

Structural variations (SVs)—large-scale changes in DNA sequence—play a crucial role in shaping traits such as yield, quality, and environmental adaptation in crops.

On the left side, in vitro preassembled DNA circuits are delivered into living cells. Alternatively, on the right side, RNA pregates are autonomously transcribed from the chromosome or plasmids to be ...