As such, p21 acts as an effective inhibitor of S-phase DNA synthesis though permits NER, leading to the proposal that p21 acts to preferentially select polymerase processivity factors depending …

Jul 20, 2025 · The p21 protein is a fundamental regulator of cell behavior. Encoded by the CDKN1A gene, p21 is a cyclin-dependent kinase inhibitor that governs the pace of cell …

As a downstream target of p53, p21 is a powerful pan-inhibitor of CDK that plays a considerable role in cell cycle regulation, DNA repair, and cellular senescence [57,68,69].

This article offers a comprehensive overview of 3 senescence phenotypes involving p21, elucidates the differences between p21 and p16, and examines the role of p21-dependent …

In normal cells, p21 maintains its gen-uine signature function as a cell cycle inhibitor and antiproliferative effector. p21 can mediate cellular senescence via p53-dependent and …

Jan 1, 2017 · Traditionally, the p21 protein has been defined as an inhibitor of cyclin-dependent kinases (CDKs). Inhibition of this group of enzymes by p21 leads to the cessation of cell …

Feb 3, 2020 · Cyclin-dependent kinase inhibitor 1, also known as CDK-interacting protein 1, or more simply as p21, is a cell cycle inhibitor that promotes both CDK/cyclin inhibition as well as …

Jul 3, 2019 · When cancer is being treated with chemotherapy, surviving cells can acquire a proliferative or senescent phenotype. The cyclin-dependent kinase inhibitor p21 is usually …

May 14, 2009 · p21 has a well-known role in mediating p53-induced growth arrest. However, this protein can affect many other cellular functions and is activated independently of p53.

In this review, we will focus on the multiple functions of p21 in cell cycle regulation, apoptosis and gene transcription after DNA damage and briefly discuss the pathways and factors that have …