These RNA catalysts may have pharmaceutical applications. For example, a ribozyme has been designed to cleave the RNA of HIV. If such a ribozyme were made by a cell, all incoming virus …

Jan 19, 2026 · Discuss the significance of ribozyme catalysis in the RNA world hypothesis and how modern ribozymes (and engineered artificial ribozymes) inform our understanding of early biocatalysis.

In this context, there was much rejoicing when a series of papers over the last few years established that the ribosome, that gigantic particle that was always thought to contain a large RNA framework for …

Jul 24, 2023 · A ribozyme is a ribonucleic acid (RNA) enzyme that catalyzes a chemical reaction. The ribozyme catalyses specific reactions in a similar way to that of protein enzymes.

5 days ago · To persist, such a ribozyme would need to act as an RNA-dependent RNA polymerase, catalyzing the two steps of a self-replication cycle — the synthesis of its complementary strand ( (-) …

Jun 15, 2025 · A ribozyme is a ribonucleic acid (RNA) molecule that can catalyze a specific biochemical reaction, functioning much like a protein-based enzyme. The discovery of ribozymes in the early …

Nov 25, 2025 · Glucosamine-6-phosphate riboswitch ribozyme (gim ribozyme) The glmS ribozyme is a self-cleaving RNA motif found in the 5′-UTR of the glmS gene in many Gram-positive bacteria, and it …

A ribozyme is an RNA molecule that can cleave phosphodiester bonds independently of protein-based enzymes. It can be delivered in vivo as synthetic oligonucleotides or expressed from transgenes, …

Jan 10, 2026 · To enable a sensed RNA to activate diverse RNA effectors, the authors engineer a programmable dual-site ribozyme that, upon RNA trigger binding, self-cleaves to release an …

The well-established natural ribozymes are the hammerhead, hairpin, hepatitis delta virus (HDV), Varkud Satellite (VS), GlmS, twister, twister sister, pistol and hatchet ribozyme, which make up the …